PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unkn...

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Detalles Bibliográficos
Autores principales: Rajapakse, Dinusha, Chen, Mei, Curtis, Tim M., Xu, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680555/
https://www.ncbi.nlm.nih.gov/pubmed/29016360
http://dx.doi.org/10.18632/aging.101299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680555/
https://www.ncbi.nlm.nih.gov/pubmed/29016360
http://dx.doi.org/10.18632/aging.101299

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