Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways

Macrophage polarization is implicated in the inflammation in obesity. The aim of the present study was to examine the anti-inflammatory activities of botanical triterpene celastrol against diet-induced obesity. We treated diet-induced obese C57BL/6N male mice with celastrol (5, 7.5 mg/kg/d) for 3 we...

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Detalles Bibliográficos
Autores principales: Luo, Dan, Guo, Yumeng, Cheng, Yuanyuan, Zhao, Jia, Wang, Yu, Rong, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680556/
https://www.ncbi.nlm.nih.gov/pubmed/29040966
http://dx.doi.org/10.18632/aging.101302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680556/
https://www.ncbi.nlm.nih.gov/pubmed/29040966
http://dx.doi.org/10.18632/aging.101302

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