A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Here, we used MCF7 cells as a model system to interrogate how MYC/RAS co-operativity contributes to metabolic flux and stemness in breast cancer cells. We compared the behavior of isogenic MCF7 cell lines transduced with c-Myc or H-Ras (G12V), either individually or in combination. Cancer stem cell...

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Detalles Bibliográficos
Autores principales: Ozsvari, Bela, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680558/
https://www.ncbi.nlm.nih.gov/pubmed/29080556
http://dx.doi.org/10.18632/aging.101304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680558/
https://www.ncbi.nlm.nih.gov/pubmed/29080556
http://dx.doi.org/10.18632/aging.101304

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