SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

The mechanism by which p53 suppresses tumorigenesis remains poorly understood. In the context of aberrant activation of the JAK/STAT5 pathway, SOCS1 is required for p53 activation and the regulation of cellular senescence. In order to identify p53 target genes acting during the senescence response t...

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Detalles Bibliográficos
Autores principales: Saint-Germain, Emmanuelle, Mignacca, Lian, Vernier, Mathieu, Bobbala, Diwakar, Ilangumaran, Subburaj, Ferbeyre, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680560/
https://www.ncbi.nlm.nih.gov/pubmed/29081404
http://dx.doi.org/10.18632/aging.101306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680560/
https://www.ncbi.nlm.nih.gov/pubmed/29081404
http://dx.doi.org/10.18632/aging.101306

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