SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy

The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD(+)-dependent manner and is implicated in cellular senescence and aging. Here we reveal a novel function of SIRT4 in mitochondrial morphology/quality control and regulation of mitophagy. We report that mode...

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Detalles Bibliográficos
Autores principales: Lang, Alexander, Anand, Ruchika, Altinoluk-Hambüchen, Simone, Ezzahoini, Hakima, Stefanski, Anja, Iram, Afshin, Bergmann, Laura, Urbach, Jennifer, Böhler, Philip, Hänsel, Jan, Franke, Manuel, Stühler, Kai, Krutmann, Jean, Scheller, Jürgen, Stork, Björn, Reichert, Andreas S., Piekorz, Roland P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680561/
https://www.ncbi.nlm.nih.gov/pubmed/29081403
http://dx.doi.org/10.18632/aging.101307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680561/
https://www.ncbi.nlm.nih.gov/pubmed/29081403
http://dx.doi.org/10.18632/aging.101307

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