BCR–ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the BCR–ABL1 tyrosine kinase (TK). The development of TK inhibitors (TKIs) revolutionized the treatment of CML patients. However, TKIs are not effective to those at advanced phases when amplified BCR–ABL1 levels and increased g...

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Detalles Bibliográficos
Autores principales: Pereira, Welbert O, De Carvalho, Daniel D, Zenteno, Maria Emilia, Ribeiro, Beatriz F, Jacysyn, Jacqueline F, Sardinha, Luiz R, Zanichelli, Maria A, Hamerschlak, Nelson, Jones, Gareth E, Pagnano, Katia B, Castro, Fabiola A, Calle, Yolanda, Amarante-Mendes, Gustavo P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680580/
https://www.ncbi.nlm.nih.gov/pubmed/29022901
http://dx.doi.org/10.1038/cddis.2017.458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680580/
https://www.ncbi.nlm.nih.gov/pubmed/29022901
http://dx.doi.org/10.1038/cddis.2017.458

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