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miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680589/ https://www.ncbi.nlm.nih.gov/pubmed/28981116 http://dx.doi.org/10.1038/cddis.2017.467 |