miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation

Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here,...

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Detalles Bibliográficos
Autores principales: Zhang, Mei, Zhang, Qun, Hu, Yali, Xu, Lu, Jiang, Yue, Zhang, Chunxue, Ding, Lijun, Jiang, Ruiwei, Sun, Jianxin, Sun, Haixiang, Yan, Guijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680589/
https://www.ncbi.nlm.nih.gov/pubmed/28981116
http://dx.doi.org/10.1038/cddis.2017.467

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