The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

BACKGROUND: HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LED...

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Detalles Bibliográficos
Autores principales: Amadori, Céline, van der Velden, Yme Ubeles, Bonnard, Damien, Orlov, Igor, van Bel, Nikki, Le Rouzic, Erwann, Miralles, Laia, Brias, Julie, Chevreuil, Francis, Spehner, Daniele, Chasset, Sophie, Ledoussal, Benoit, Mayr, Luzia, Moreau, François, García, Felipe, Gatell, José, Zamborlini, Alessia, Emiliani, Stéphane, Ruff, Marc, Klaholz, Bruno P., Moog, Christiane, Berkhout, Ben, Plana, Montserrat, Benarous, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680779/
https://www.ncbi.nlm.nih.gov/pubmed/29121950
http://dx.doi.org/10.1186/s12977-017-0373-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680779/
https://www.ncbi.nlm.nih.gov/pubmed/29121950
http://dx.doi.org/10.1186/s12977-017-0373-2

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