Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding

The increased number of bispecific antibodies (BsAb) under therapeutic development has resulted in a need for mouse surrogate BsAbs. Here, we describe a one-step method for generating highly pure mouse BsAbs suitable for in vitro and in vivo studies. We identify two mutations in the mouse IgG2a and...

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Detalles Bibliográficos
Autores principales: Zwolak, Adam, Armstrong, Anthony A., Tam, Susan H., Pardinas, Jose R., Goulet, Dennis R., Zheng, Songmao, Brosnan, Kerry, Emmell, Eva, Luo, Jeffrey, Gilliland, Gary L., Chiu, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680793/
https://www.ncbi.nlm.nih.gov/pubmed/28898162
http://dx.doi.org/10.1080/19420862.2017.1375639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680793/
https://www.ncbi.nlm.nih.gov/pubmed/28898162
http://dx.doi.org/10.1080/19420862.2017.1375639

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