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IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development
A central dogma in immunology is that an antibody's in vivo functionality is mediated by 2 independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680800/ https://www.ncbi.nlm.nih.gov/pubmed/28812955 http://dx.doi.org/10.1080/19420862.2017.1367074 |