Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics

Affinity-matured, functional anti-pathogen antibodies are present at low frequencies in natural human repertoires. These antibodies are often excellent candidates for therapeutic monoclonal antibodies. However, mining natural human antibody repertoires is a challenge. In this study, we demonstrate a...

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Detalles Bibliográficos
Autores principales: Adler, Adam S., Mizrahi, Rena A., Spindler, Matthew J., Adams, Matthew S., Asensio, Michael A., Edgar, Robert C., Leong, Jackson, Leong, Renee, Roalfe, Lucy, White, Rebecca, Goldblatt, David, Johnson, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680809/
https://www.ncbi.nlm.nih.gov/pubmed/28846502
http://dx.doi.org/10.1080/19420862.2017.1371383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680809/
https://www.ncbi.nlm.nih.gov/pubmed/28846502
http://dx.doi.org/10.1080/19420862.2017.1371383

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