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Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function

Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function. A detailed characterization of the effects of CXCL12 on thrombin-mediated human lung endothelial hyperpermeability is lack...

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Detalles Bibliográficos
Autores principales: Cheng, You-Hong, Eby, Jonathan M., LaPorte, Heather M., Volkman, Brian F., Majetschak, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681266/
https://www.ncbi.nlm.nih.gov/pubmed/29125867
http://dx.doi.org/10.1371/journal.pone.0187949