FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

OBJECTIVE: Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite corecep...

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Detalles Bibliográficos
Autores principales: Chen, Mark Z., Chang, Joshua C., Zavala-Solorio, Jose, Kates, Lance, Thai, Minh, Ogasawara, Annie, Bai, Xiaobo, Flanagan, Sean, Nunez, Victor, Phamluong, Khanhky, Ziai, James, Newman, Robert, Warming, Søren, Kolumam, Ganesh, Sonoda, Junichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681280/
https://www.ncbi.nlm.nih.gov/pubmed/29107292
http://dx.doi.org/10.1016/j.molmet.2017.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681280/
https://www.ncbi.nlm.nih.gov/pubmed/29107292
http://dx.doi.org/10.1016/j.molmet.2017.09.003

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