U6 snRNA expression prevents toxicity in TDP-43-knockdown cells

Depletion of amyotrophic lateral sclerosis (ALS)-associated transactivation response (TAR) RNA/DNA-binding protein 43 kDa (TDP-43) alters splicing efficiency of multiple transcripts and results in neuronal cell death. TDP-43 depletion can also disturb expression levels of small nuclear RNAs (snRNAs)...

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Detalles Bibliográficos
Autores principales: Yahara, Masao, Kitamura, Akira, Kinjo, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681290/
https://www.ncbi.nlm.nih.gov/pubmed/29125873
http://dx.doi.org/10.1371/journal.pone.0187813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681290/
https://www.ncbi.nlm.nih.gov/pubmed/29125873
http://dx.doi.org/10.1371/journal.pone.0187813

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