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Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

Advanced head and neck squamous cell carcinoma (HNSCC) remains a therapeutic challenge due to the development of therapy resistance. Several studies have implicated the development of cancer stem cells as a possible mechanism for therapy resistance in HNSCC. Heat shock protein 90’s (Hsp90’s) molecul...

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Detalles Bibliográficos
Autores principales: Subramanian, C., Kovatch, K.J., Sim, M.W., Wang, G., Prince, M.E., Carey, T.E., Davis, R., Blagg, B.S.J., Cohen, M.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681325/
https://www.ncbi.nlm.nih.gov/pubmed/29121598
http://dx.doi.org/10.1016/j.neo.2017.09.003