Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90 kinase clients, binding of CDK4/6 to Cdc37 is blocked by A...

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Detalles Bibliográficos
Autores principales: Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681435/
https://www.ncbi.nlm.nih.gov/pubmed/29091774
http://dx.doi.org/10.1016/j.celrep.2017.10.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681435/
https://www.ncbi.nlm.nih.gov/pubmed/29091774
http://dx.doi.org/10.1016/j.celrep.2017.10.042

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