A thermostable Cas9 with increased lifetime in human plasma

CRISPR-Cas9 is a powerful technology that has enabled genome editing in a wide range of species. However, the currently developed Cas9 homologs all originate from mesophilic bacteria, making them susceptible to degradation and unsuitable for applications requiring cleavage at elevated temperatures....

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Detalles Bibliográficos
Autores principales: Harrington, Lucas B., Paez-Espino, David, Staahl, Brett T., Chen, Janice S., Ma, Enbo, Kyrpides, Nikos C., Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681539/
https://www.ncbi.nlm.nih.gov/pubmed/29127284
http://dx.doi.org/10.1038/s41467-017-01408-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681539/
https://www.ncbi.nlm.nih.gov/pubmed/29127284
http://dx.doi.org/10.1038/s41467-017-01408-4

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