Cargando…

Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice

Approximately 40% of HIV-1 infections occur in the female genital tract (FGT), primarily through heterosexual transmission. FGT factors determining outcome of HIV-1 exposure are incompletely understood, limiting prevention strategies. Here, humanized NOD-Rag1(−/−) γc(−/−) mice differentially reconst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Philip V., Wessels, Jocelyn M., Mueller, Kristen, Vahedi, Fatemeh, Anipindi, Varun, Verschoor, Chris P., Chew, Marianne, Deshiere, Alexandre, Karniychuk, Uladzimir, Mazzulli, Tony, Tremblay, Michel J., Ashkar, Ali A., Kaushic, Charu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681573/ https://www.ncbi.nlm.nih.gov/pubmed/29127409 http://dx.doi.org/10.1038/s41598-017-15630-z

Ejemplares similares

Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice
por: Wessels, Jocelyn M., et al.
Publicado: (2021)

Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice
por: Wessels, Jocelyn M., et al.
Publicado: (2019)

The Role of IL-17 During Infections in the Female Reproductive Tract
por: Bagri, Puja, et al.
Publicado: (2022)

Comparing Current and Next-Generation Humanized Mouse Models for Advancing HIV and HIV/Mtb Co-Infection Studies
por: Lepard, Madeleine, et al.
Publicado: (2022)

Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses
por: Gillgrass, Amy, et al.
Publicado: (2021)

Role of sex hormones and the vaginal microbiome in susceptibility and mucosal immunity to HIV-1 in the female genital tract
por: Vitali, Danielle, et al.
Publicado: (2017)

High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells
por: Xiu, Fangming, et al.
Publicado: (2016)

Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells
por: Vahedi, Fatemeh, et al.
Publicado: (2017)

The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women
por: Wessels, Jocelyn M., et al.
Publicado: (2018)

LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection
por: Nazli, Aisha, et al.
Publicado: (2022)

The Anti-Inflammatory Activity of Curcumin Protects the Genital Mucosal Epithelial Barrier from Disruption and Blocks Replication of HIV-1 and HSV-2
por: Ferreira, Victor H., et al.
Publicado: (2015)

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice
por: Dykstra, Crystal, et al.
Publicado: (2016)

Differential Elevation of Inflammation and CD4(+) T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate
por: Omollo, Kenneth, et al.
Publicado: (2021)

Japanese encephalitis virus persists in the human reproductive epithelium and porcine reproductive tissues
por: Chapagain, Subash, et al.
Publicado: (2022)

Absence of Effect of Intravaginal Miconazole, Clindamycin, Nonoxynol‐9, and Tampons on the Pharmacokinetics of an Anastrozole/Levonorgestrel Intravaginal Ring
por: Nave, Rüdiger, et al.
Publicado: (2017)

Designing of the Mucoadhesive Intravaginal Spermicidal Films
por: Kawarkhe, Shilpa, et al.
Publicado: (2010)

Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier
por: Nazli, Aisha, et al.
Publicado: (2018)

Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection
por: Karniychuk, Uladzimir U, et al.
Publicado: (2013)

3466 Innovative 3D Printed Intravaginal Rings: Developing AnelleO PRO, the First Intravaginal Ring for Infertility
por: Janusziewicz, Rima, et al.
Publicado: (2019)

Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis
por: Lee, Howard Hao, et al.
Publicado: (2020)

Decontamination of Intravaginal Probes Infected by Human Papillomavirus (HPV) Using UV-C Decontamination System
por: Pichon, Maxime, et al.
Publicado: (2019)

Motivations for Intravaginal Product Use among a Cohort of Women in Los Angeles
por: Brown, Joelle M., et al.
Publicado: (2016)

Preparation and Evaluation of Intravaginal Ring Containing Drospirenone
por: Zhang, Ying, et al.
Publicado: (2013)

Intravaginal eletrical stimulation for bladder training method
por: Riccetto, Cássio L. Z.
Publicado: (2021)

Development of Hormonal Intravaginal Rings: Technology and Challenges
por: Rafiei, Fojan, et al.
Publicado: (2021)

Treatment of genitourinary syndrome of menopause: the potential effects of intravaginal ultralow-concentration oestriol and intravaginal dehydroepiandrosterone on quality of life and sexual function
por: La Rosa, Valentina Lucia, et al.
Publicado: (2019)

CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes
por: Udenze, Daniel, et al.
Publicado: (2022)

The Induction of Tumours in Mice by Intravaginal Application of Chemical Compounds
por: Boyland, E., et al.
Publicado: (1961)

Fetal facial expression in response to intravaginal music emission
por: López-Teijón, Marisa, et al.
Publicado: (2015)

An intravaginal ring for real-time evaluation of adherence to therapy
por: Moss, John A., et al.
Publicado: (2017)

An automated controlled-release device for intravaginal hormone delivery
por: Masello, M., et al.
Publicado: (2020)

Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms
por: Hapgood, Janet P., et al.
Publicado: (2018)

Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model
por: Felker, Allison M., et al.
Publicado: (2021)

Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa
por: Vitali, Danielle, et al.
Publicado: (2020)

Considerations for the rational design of a Chlamydia vaccine
por: Liang, Steven, et al.
Publicado: (2016)

Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract
por: Dizzell, Sara, et al.
Publicado: (2019)

Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1
por: Schwecht, Ingrid, et al.
Publicado: (2023)

Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine
por: Chen, Yufei, et al.
Publicado: (2014)

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies
por: Thurman, Andrea Ries, et al.
Publicado: (2013)

Intravaginal practices and lactobacilli colonization among women in Accra, Ghana
por: McCarthy, Francisca Nana-Aba, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jalt81mnf4lesmhcfm0u6loiu6