Cargando…
Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice
Approximately 40% of HIV-1 infections occur in the female genital tract (FGT), primarily through heterosexual transmission. FGT factors determining outcome of HIV-1 exposure are incompletely understood, limiting prevention strategies. Here, humanized NOD-Rag1(−/−) γc(−/−) mice differentially reconst...
Autores principales: | Nguyen, Philip V., Wessels, Jocelyn M., Mueller, Kristen, Vahedi, Fatemeh, Anipindi, Varun, Verschoor, Chris P., Chew, Marianne, Deshiere, Alexandre, Karniychuk, Uladzimir, Mazzulli, Tony, Tremblay, Michel J., Ashkar, Ali A., Kaushic, Charu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681573/ https://www.ncbi.nlm.nih.gov/pubmed/29127409 http://dx.doi.org/10.1038/s41598-017-15630-z |
Ejemplares similares
-
Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice
por: Wessels, Jocelyn M., et al.
Publicado: (2021) -
Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice
por: Wessels, Jocelyn M., et al.
Publicado: (2019) -
The Role of IL-17 During Infections in the Female Reproductive Tract
por: Bagri, Puja, et al.
Publicado: (2022) -
Comparing Current and Next-Generation Humanized Mouse Models for Advancing HIV and HIV/Mtb Co-Infection Studies
por: Lepard, Madeleine, et al.
Publicado: (2022) -
Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses
por: Gillgrass, Amy, et al.
Publicado: (2021)