The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity

Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries. However, organisms need to restrict TE activity to ensure genome integrity, especially in germline c...

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Detalles Bibliográficos
Autores principales: Ernst, Christina, Odom, Duncan T., Kutter, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681665/
https://www.ncbi.nlm.nih.gov/pubmed/29127279
http://dx.doi.org/10.1038/s41467-017-01049-7
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author Ernst, Christina
Odom, Duncan T.
Kutter, Claudia
author_facet Ernst, Christina
Odom, Duncan T.
Kutter, Claudia
author_sort Ernst, Christina
collection PubMed
description Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries. However, organisms need to restrict TE activity to ensure genome integrity, especially in germline cells to protect the transmission of genetic information to the next generation. This review features our current understandings of mammalian PIWI-interacting RNAs (piRNAs) and their role in TE regulation in spermatogenesis. Here we discuss functional implication and explore additional molecular mechanisms that inhibit transposon activity and altogether illustrate the paradoxical arms race between genome evolution and stability.
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spelling pubmed-56816652017-11-16 The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity Ernst, Christina Odom, Duncan T. Kutter, Claudia Nat Commun Review Article Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries. However, organisms need to restrict TE activity to ensure genome integrity, especially in germline cells to protect the transmission of genetic information to the next generation. This review features our current understandings of mammalian PIWI-interacting RNAs (piRNAs) and their role in TE regulation in spermatogenesis. Here we discuss functional implication and explore additional molecular mechanisms that inhibit transposon activity and altogether illustrate the paradoxical arms race between genome evolution and stability. Nature Publishing Group UK 2017-11-10 /pmc/articles/PMC5681665/ /pubmed/29127279 http://dx.doi.org/10.1038/s41467-017-01049-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Ernst, Christina
Odom, Duncan T.
Kutter, Claudia
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_full The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_fullStr The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_full_unstemmed The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_short The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
title_sort emergence of pirnas against transposon invasion to preserve mammalian genome integrity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681665/
https://www.ncbi.nlm.nih.gov/pubmed/29127279
http://dx.doi.org/10.1038/s41467-017-01049-7
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