Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Elevated sphingosine 1-phosphate (S1P) is detrimental in Sickle Cell Disease (SCD), but the mechanistic basis remains obscure. Here, we report that increased erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilitates deoxyHbS anchoring to the membrane, induces release of membrane-bound...

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Detalles Bibliográficos
Autores principales: Sun, Kaiqi, D’Alessandro, Angelo, Ahmed, Mostafa H., Zhang, Yujin, Song, Anren, Ko, Tzu-Ping, Nemkov, Travis, Reisz, Julie A., Wu, Hongyu, Adebiyi, Morayo, Peng, Zhangzhe, Gong, Jing, Liu, Hong, Huang, Aji, Wen, Yuan Edward, Wen, Alexander Q., Berka, Vladimir, Bogdanov, Mikhail V., Abdulmalik, Osheiza, Han, Leng, Tsai, Ah-lim, Idowu, Modupe, Juneja, Harinder S., Kellems, Rodney E., Dowhan, William, Hansen, Kirk C., Safo, Martin K., Xia, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681684/
https://www.ncbi.nlm.nih.gov/pubmed/29127281
http://dx.doi.org/10.1038/s41598-017-13667-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681684/
https://www.ncbi.nlm.nih.gov/pubmed/29127281
http://dx.doi.org/10.1038/s41598-017-13667-8

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