Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8(+) T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating adenovirus encoding a chimeric, membrane-bound CD40 ligand (ISF35). Intratumoral admin...

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Detalles Bibliográficos
Autores principales: Singh, Manisha, Vianden, Christina, Cantwell, Mark J., Dai, Zhimin, Xiao, Zhilan, Sharma, Meenu, Khong, Hiep, Jaiswal, Ashvin R., Faak, Faisal, Hailemichael, Yared, Janssen, L. M. E., Bharadwaj, Uddalak, Curran, Michael A., Diab, Adi, Bassett, Roland L., Tweardy, David J., Hwu, Patrick, Overwijk, Willem W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682289/
https://www.ncbi.nlm.nih.gov/pubmed/29129918
http://dx.doi.org/10.1038/s41467-017-01572-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682289/
https://www.ncbi.nlm.nih.gov/pubmed/29129918
http://dx.doi.org/10.1038/s41467-017-01572-7

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