MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21

MYC proto-oncogene family including c-myc and n-myc (MYCN) are critical for normal cell development and tumorigenesis. Overexpression of c-myc causes acute erythroleukemia in vivo. However, the role of MYCN in acute erythroleukemia remains poorly understood. In this study, we found that the patients...

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Detalles Bibliográficos
Autores principales: Liu, Li, Xu, Feng, Chang, Chun-Kang, He, Qi, Wu, Ling-Yun, Zhang, Zheng, Li, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682688/
https://www.ncbi.nlm.nih.gov/pubmed/29022893
http://dx.doi.org/10.1038/cddis.2017.526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682688/
https://www.ncbi.nlm.nih.gov/pubmed/29022893
http://dx.doi.org/10.1038/cddis.2017.526

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