Structure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity

Four mutations (N23A, Y90A, R110A and F177A) were introduced into S19, a vaccine candidate for staphylococcal enterotoxin B (SEB), resulting in a lower binding affinity towards the T-cell receptor beta chain (TCB) and reducing its superantigen activity. The structure of S19 was solved and was superp...

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Detalles Bibliográficos
Autores principales: Jeong, Woo Hyeon, Song, Dong Hyun, Hur, Gyeung Haeng, Jeong, Seong Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683028/
https://www.ncbi.nlm.nih.gov/pubmed/29095152
http://dx.doi.org/10.1107/S2053230X17014844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683028/
https://www.ncbi.nlm.nih.gov/pubmed/29095152
http://dx.doi.org/10.1107/S2053230X17014844

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