YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC

The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased...

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Detalles Bibliográficos
Autores principales: Ghiso, Elena, Migliore, Cristina, Ciciriello, Vito, Morando, Elena, Petrelli, Annalisa, Corso, Simona, De Luca, Emmanuele, Gatti, Gaia, Volante, Marco, Giordano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683041/
https://www.ncbi.nlm.nih.gov/pubmed/29136529
http://dx.doi.org/10.1016/j.neo.2017.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683041/
https://www.ncbi.nlm.nih.gov/pubmed/29136529
http://dx.doi.org/10.1016/j.neo.2017.10.003

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