PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Metabolic reprogramming is a hallmark of cancer. Herein we discovered that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Fabao, Ma, Fengfei, Wang, Yuyuan, Hao, Ling, Zeng, Hao, Jia, Chenxi, Wang, Yidan, Liu, Peng, Ong, Irene M, Li, Baobin, Chen, Guojun, Jiang, Jiaoyang, Gong, Shaoqin, Li, Lingjun, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683091/
https://www.ncbi.nlm.nih.gov/pubmed/29058718
http://dx.doi.org/10.1038/ncb3630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683091/
https://www.ncbi.nlm.nih.gov/pubmed/29058718
http://dx.doi.org/10.1038/ncb3630

Ejemplares similares