Cargando…

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Metabolic reprogramming is a hallmark of cancer. Herein we discovered that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Fabao, Ma, Fengfei, Wang, Yuyuan, Hao, Ling, Zeng, Hao, Jia, Chenxi, Wang, Yidan, Liu, Peng, Ong, Irene M, Li, Baobin, Chen, Guojun, Jiang, Jiaoyang, Gong, Shaoqin, Li, Lingjun, Xu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683091/ https://www.ncbi.nlm.nih.gov/pubmed/29058718 http://dx.doi.org/10.1038/ncb3630

Ejemplares similares

Oncogenic virus-induced aerobic glycolysis and tumorigenesis
por: Yu, Li, et al.
Publicado: (2018)

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
por: Wang, Chunqing, et al.
Publicado: (2020)

The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
por: Wang, Jing‐Zi, et al.
Publicado: (2021)

Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing
por: Zhao, Jing, et al.
Publicado: (2020)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis
por: Li, Xiaoping, et al.
Publicado: (2020)

Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession
por: Liu, Yuan-Rong, et al.
Publicado: (2022)

MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2
por: Li, Hui, et al.
Publicado: (2019)

Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis
por: Gao, Mingjun, et al.
Publicado: (2021)

Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
por: Shishkova, Evgenia, et al.
Publicado: (2017)

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis
por: Guo, Jianshuang, et al.
Publicado: (2019)

Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes
por: Wei, Xiang, et al.
Publicado: (2020)

Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
por: Zhang, Qiqi, et al.
Publicado: (2021)

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis
por: Gao, Peng, et al.
Publicado: (2020)

Rab25 acts as an oncogene and participates in the regulation of aerobic glycolysis via PKM2 in gastric adenocarcinoma
por: Zheng, Tianyu, et al.
Publicado: (2021)

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
por: Li, Tong, et al.
Publicado: (2019)

Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis
por: Mei, Shuya, et al.
Publicado: (2022)

RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
por: Xu, Debin, et al.
Publicado: (2023)

The Interaction Between lncRNA SNHG6 and hnRNPA1 Contributes to the Growth of Colorectal Cancer by Enhancing Aerobic Glycolysis Through the Regulation of Alternative Splicing of PKM
por: Lan, Zhixian, et al.
Publicado: (2020)

miR-142-3p Modulates Cell Invasion and Migration via PKM2-Mediated Aerobic Glycolysis in Colorectal Cancer
por: Ren, JunYu, et al.
Publicado: (2021)

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis
por: Zhang, Zhiyong, et al.
Publicado: (2022)

KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
por: Varlı, Mücahit, et al.
Publicado: (2023)

The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis
por: Cui, Kaili, et al.
Publicado: (2022)

FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis
por: Zhang, Wei, et al.
Publicado: (2021)

Linc-UROD stabilizes ENO1 and PKM to strengthen glycolysis, proliferation and migration of pancreatic cancer cells
por: He, Yuan, et al.
Publicado: (2022)

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
por: Bluemlein, Katharina, et al.
Publicado: (2011)

Automethylation of CARM1 allows coupling of transcription and mRNA splicing
por: Kuhn, Peter, et al.
Publicado: (2011)

Vacuolar H(+)-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling
por: Son, Sung Wook, et al.
Publicado: (2019)

Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
por: Fan, Ni, et al.
Publicado: (2022)

Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
por: Li, Baobin, et al.
Publicado: (2017)

FOXO3a-SIRT6 axis suppresses aerobic glycolysis in melanoma
por: Dong, Zhen, et al.
Publicado: (2020)

PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation
por: Lv, Mengzhu, et al.
Publicado: (2021)

IGF2BP3 May Contributes to Lung Tumorigenesis by Regulating the Alternative Splicing of PKM
por: Xueqing, Huang, et al.
Publicado: (2020)

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
por: Liang, Ji, et al.
Publicado: (2016)

SMYD3 promotes aerobic glycolysis in diffuse large B-cell lymphoma via H3K4me3-mediated PKM2 transcription
por: Tian, Tian, et al.
Publicado: (2022)

A feedback loop between NONHSAT024276 and PTBP1 inhibits tumor progression and glycolysis in HCC by increasing the PKM1/PKM2 ratio
por: Li, Yuwei, et al.
Publicado: (2022)

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
por: Han, Dongfeng, et al.
Publicado: (2015)

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
por: Xie, Min, et al.
Publicado: (2016)

Aerobic Glycolysis: Beyond Proliferation
por: Jones, William, et al.
Publicado: (2015)

Re: CaRMS at 50
por: MacFarlane, Malcolm
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1v9damjbid97mhfph0060s5hp8