Detection of Dysregulated Protein Association Networks by High-Throughput Proteomics Predicts Cancer Vulnerabilities

The formation of protein complexes and the co-regulation of the cellular concentrations of proteins are essential mechanisms for cellular signaling and for maintaining homeostasis. Here we use isobaric labeling multiplexed proteomics to analyze protein co-regulation and show that this allows the ide...

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Detalles Bibliográficos
Autores principales: Lapek, John D., Greninger, Patricia, Morris, Robert, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Benes, Cyril H., Haas, Wilhelm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683351/
https://www.ncbi.nlm.nih.gov/pubmed/28892078
http://dx.doi.org/10.1038/nbt.3955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683351/
https://www.ncbi.nlm.nih.gov/pubmed/28892078
http://dx.doi.org/10.1038/nbt.3955

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