Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma

Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for novel therapeutic strategies in cancer. Here we show that acute inhibition of EGFR-driven glucose metabolism induces minimal cell death, yet lowers the apoptotic threshold in a subset of patient-derived glioblas...

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Detalles Bibliográficos
Autores principales: Mai, Wilson X., Gosa, Laura, Daniels, Veerle W., Ta, Lisa, Tsang, Jonathan E., Higgins, Brian, Gilmore, W. Blake, Bayley, Nicholas A., Harati, Mitra Dehghan, Lee, Jason T., Yong, William H., Kornblum, Harley I., Bensinger, Steven J., Mischel, Paul S., Rao, P. Nagesh, Clark, Peter M., Cloughesy, Timothy F., Letai, Anthony, Nathanson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683421/
https://www.ncbi.nlm.nih.gov/pubmed/29035366
http://dx.doi.org/10.1038/nm.4418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683421/
https://www.ncbi.nlm.nih.gov/pubmed/29035366
http://dx.doi.org/10.1038/nm.4418

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