A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation

Oxidatively modified forms of proteins accumulate during aging. Oxidized protein conformers might act as intermediates in the formation of amyloids in age-related disorders. However, it is not known whether this amyloidogenic conversion requires an extensive protein oxidative damage or it can be pro...

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Detalles Bibliográficos
Autores principales: Marinelli, Patrizia, Navarro, Susanna, Graña-Montes, Ricardo, Bañó-Polo, Manuel, Fernández, María Rosario, Papaleo, Elena, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684091/
https://www.ncbi.nlm.nih.gov/pubmed/29132128
http://dx.doi.org/10.1016/j.redox.2017.10.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684091/
https://www.ncbi.nlm.nih.gov/pubmed/29132128
http://dx.doi.org/10.1016/j.redox.2017.10.022

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