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A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation
Oxidatively modified forms of proteins accumulate during aging. Oxidized protein conformers might act as intermediates in the formation of amyloids in age-related disorders. However, it is not known whether this amyloidogenic conversion requires an extensive protein oxidative damage or it can be pro...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684091/ https://www.ncbi.nlm.nih.gov/pubmed/29132128 http://dx.doi.org/10.1016/j.redox.2017.10.022 |