Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor

Nitrapyrin, a nitrification inhibitor, produces liver tumors in mice at high doses. Several experiments were performed to investigate molecular, cellular, and apical endpoints to define the key events leading to the tumor formation. These data support a mode-of-action (MoA) characterized by constitu...

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Detalles Bibliográficos
Autores principales: LaRocca, Jessica L., Rasoulpour, Reza J., Gollapudi, B. Bhaskar, Eisenbrandt, David L., Murphy, Lynea A., LeBaron, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684092/
https://www.ncbi.nlm.nih.gov/pubmed/29159133
http://dx.doi.org/10.1016/j.toxrep.2017.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684092/
https://www.ncbi.nlm.nih.gov/pubmed/29159133
http://dx.doi.org/10.1016/j.toxrep.2017.10.007

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