Cargando…

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

The precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear. The PLCγ signaling pathway is critical for antigen receptor-mediated lymphocyte activation, but its function in cytokine signaling is unknown. Here we show that PLCγ1/PLCγ2 double deficiency in mice b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Mei, Chen, Yuhong, Zeng, Hu, Zheng, Yongwei, Fu, Guoping, Zhu, Wen, Broeckel, Ulrich, Aggarwal, Praful, Turner, Amy, Neale, Geoffrey, Guy, Cliff, Zhu, Nan, Chi, Hongbo, Wen, Renren, Wang, Demin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684131/ https://www.ncbi.nlm.nih.gov/pubmed/29133930 http://dx.doi.org/10.1038/s41467-017-01388-5

Ejemplares similares

The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes
por: Liu, Zejun, et al.
Publicado: (2015)

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1
por: Zheng, Yongwei, et al.
Publicado: (2015)

CXCR5(+)PD-1(+) follicular helper CD8 T cells control B cell tolerance
por: Chen, Yuhong, et al.
Publicado: (2019)

Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
por: Fu, Guoping, et al.
Publicado: (2010)

Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator
por: Reeme, Allison E., et al.
Publicado: (2018)

A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR and PLCγ/ERK Signaling and Elicits Apoptotic, Antiangiogenic, and Antitumor Activities
por: Namjoo, Mohadeseh, et al.
Publicado: (2023)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Comprehensive evaluation of AmpliSeq transcriptome, a novel targeted whole transcriptome RNA sequencing methodology for global gene expression analysis
por: Li, Wenli, et al.
Publicado: (2015)

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T(reg) subsets to protect tissue homeostasis
por: Chapman, Nicole M., et al.
Publicado: (2018)

Involvement of Src kinases and PLCγ2 in clot retraction
por: Suzuki-Inoue, Katsue, et al.
Publicado: (2007)

The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
por: Jackson, Jacob T., et al.
Publicado: (2021)

PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis
por: Dell'Accio, Francesco, et al.
Publicado: (2015)

IFN-γ mediates Paneth cell death via suppression of mTOR
por: Araujo, Alessandra, et al.
Publicado: (2021)

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β
por: Sun, Panpan, et al.
Publicado: (2022)

Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding
por: Yasuda, Tomoharu, et al.
Publicado: (2000)

The Role of mTOR and Injury in Developing Salispheres
por: Saleem, Rimah, et al.
Publicado: (2023)

nWASP Inhibition Increases Wound Healing via TrKb/PLCγ Signalling
por: Frugtniet, Bethan A., et al.
Publicado: (2023)

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
por: Chen, Yuhong, et al.
Publicado: (2011)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

PLC-γ2 is essential for formation and maintenance of memory B cells
por: Hikida, Masaki, et al.
Publicado: (2009)

Conformational switches that control the TEC kinase – PLCγ signaling axis
por: Lowe, Jacques, et al.
Publicado: (2022)

PLCγ1 promotes phase separation of T cell signaling components
por: Zeng, Longhui, et al.
Publicado: (2021)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro
por: Chen, Jin, et al.
Publicado: (2023)

mTOR Links Environmental Signals to T Cell Fate Decisions
por: Chapman, Nicole M., et al.
Publicado: (2015)

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis
por: Zeng, Hu, et al.
Publicado: (2018)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Vitexin suppresses renal cell carcinoma by regulating mTOR pathways
por: Li, Yuhong, et al.
Publicado: (2020)

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
por: Hajicek, Nicole, et al.
Publicado: (2019)

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
por: Lyu, Jing-Wei, et al.
Publicado: (2019)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
por: Wen, Wen, et al.
Publicado: (2020)

mTOR complexes differentially orchestrates eosinophil development in allergy
por: Zhu, Chen, et al.
Publicado: (2018)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells
por: Guittard, Geoffrey, et al.
Publicado: (2018)

Associating bovine herpesvirus 1 envelope glycoprotein gD with activated phospho-PLC-γ1(S1248)
por: Liu, Chang, et al.
Publicado: (2023)

T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1
por: Wang, Qi-Long, et al.
Publicado: (2019)

RNA Expression Profiling of Human iPSC-Derived Cardiomyocytes in a Cardiac Hypertrophy Model
por: Aggarwal, Praful, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cr8buvesqi7cn52ha9llue9lmb