GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

GyrI-like proteins are widely distributed in prokaryotes and eukaryotes, and recognized as small-molecule binding proteins. Here, we identify a subfamily of these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydrolysis of the potent DNA-alkylating agents yatakemycin...

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Detalles Bibliográficos
Autores principales: Yuan, Hua, Zhang, Jinru, Cai, Yujuan, Wu, Sheng, Yang, Kui, Chan, H. C. Stephen, Huang, Wei, Jin, Wen-Bing, Li, Yan, Yin, Yue, Igarashi, Yasuhiro, Yuan, Shuguang, Zhou, Jiahai, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684135/
https://www.ncbi.nlm.nih.gov/pubmed/29133784
http://dx.doi.org/10.1038/s41467-017-01508-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684135/
https://www.ncbi.nlm.nih.gov/pubmed/29133784
http://dx.doi.org/10.1038/s41467-017-01508-1

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