Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype

Amyotrophic lateral sclerosis (ALS) is underpinned by an oligogenic rare variant architecture. Identified genetic variants of ALS include RNA-binding proteins containing prion-like domains (PrLDs). We hypothesized that screening genes encoding additional similar proteins will yield novel genetic cau...

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Detalles Bibliográficos
Autores principales: Cooper-Knock, Johnathan, Robins, Henry, Niedermoser, Isabell, Wyles, Matthew, Heath, Paul R., Higginbottom, Adrian, Walsh, Theresa, Kazoka, Mbombe, Ince, Paul G., Hautbergue, Guillaume M., McDermott, Christopher J., Kirby, Janine, Shaw, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684183/
https://www.ncbi.nlm.nih.gov/pubmed/29170628
http://dx.doi.org/10.3389/fnmol.2017.00370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684183/
https://www.ncbi.nlm.nih.gov/pubmed/29170628
http://dx.doi.org/10.3389/fnmol.2017.00370

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