Blastocyst Formation Rate and Transgene Expression are Associated with Gene Insertion into Safe and Non-Safe Harbors in the Cattle Genome

Integration target site is the most important factor in successful production of transgenic animals. However, stable expression of transgene without disturbing the function of the host genome depends on promoter methylation, transgene copy number and transcriptional activity in integration regions....

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Detalles Bibliográficos
Autores principales: Ghahfarokhi, Milad Khorramian, Dormiani, Kianoush, Mohammadi, Ali, Jafarpour, Farnoosh, Nasr-Esfahani, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684190/
https://www.ncbi.nlm.nih.gov/pubmed/29133827
http://dx.doi.org/10.1038/s41598-017-15648-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684190/
https://www.ncbi.nlm.nih.gov/pubmed/29133827
http://dx.doi.org/10.1038/s41598-017-15648-3

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