Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason APOE4 is associated with increased AD risk remains a source of debate. Neuronal hyperactivity is an early phenotype in both AD mouse models and in human AD, which...

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Detalles Bibliográficos
Autores principales: Nuriel, Tal, Angulo, Sergio L., Khan, Usman, Ashok, Archana, Chen, Qiuying, Figueroa, Helen Y., Emrani, Sheina, Liu, Li, Herman, Mathieu, Barrett, Geoffrey, Savage, Valerie, Buitrago, Luna, Cepeda-Prado, Efrain, Fung, Christine, Goldberg, Eliana, Gross, Steven S., Hussaini, S. Abid, Moreno, Herman, Small, Scott A., Duff, Karen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684208/
https://www.ncbi.nlm.nih.gov/pubmed/29133888
http://dx.doi.org/10.1038/s41467-017-01444-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684208/
https://www.ncbi.nlm.nih.gov/pubmed/29133888
http://dx.doi.org/10.1038/s41467-017-01444-0

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