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Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
In spite of the important applications of difluoroalkylated molecules in medicinal chemistry, to date, the reaction of difluoroalkylating reagents with unactivated, aliphatic substrates through a controllable manner remains challenging and has not been reported. Here we describe an efficient nickel-...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684216/ https://www.ncbi.nlm.nih.gov/pubmed/29133781 http://dx.doi.org/10.1038/s41467-017-01540-1 |