Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite

PURPOSE: A high interindividual variability is observed in the pharmacokinetics of clopidogrel, a widely used antiplatelet drug. In the present study, a joint parent-metabolite population pharmacokinetic model was developed to adequately describe observed concentrations of clopidogrel and its active...

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Detalles Bibliográficos
Autores principales: Danielak, Dorota, Karaźniewicz-Łada, Marta, Komosa, Anna, Burchardt, Paweł, Lesiak, Maciej, Kruszyna, Łukasz, Graczyk-Szuster, Agnieszka, Główka, Franciszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684285/
https://www.ncbi.nlm.nih.gov/pubmed/28914344
http://dx.doi.org/10.1007/s00228-017-2334-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684285/
https://www.ncbi.nlm.nih.gov/pubmed/28914344
http://dx.doi.org/10.1007/s00228-017-2334-z

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