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Development of a genetic sensor that eliminates p53 deficient cells

The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of sig...

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Detalles Bibliográficos
Autores principales: Mircetic, Jovan, Dietrich, Antje, Paszkowski-Rogacz, Maciej, Krause, Mechthild, Buchholz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684360/
https://www.ncbi.nlm.nih.gov/pubmed/29133879
http://dx.doi.org/10.1038/s41467-017-01688-w