Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic editing tool, where an inactive form of Cas9 is fused to DNA methyltransferase effectors....

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Detalles Bibliográficos
Autores principales: Saunderson, Emily A., Stepper, Peter, Gomm, Jennifer J., Hoa, Lily, Morgan, Adrienne, Allen, Michael D., Jones, J. Louise, Gribben, John G., Jurkowski, Tomasz P., Ficz, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684409/
https://www.ncbi.nlm.nih.gov/pubmed/29133799
http://dx.doi.org/10.1038/s41467-017-01078-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684409/
https://www.ncbi.nlm.nih.gov/pubmed/29133799
http://dx.doi.org/10.1038/s41467-017-01078-2

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