Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup

Apelin is one of two peptide hormones that activate the apelin receptor (AR or APJ) to regulate the cardiovascular system, central nervous system, and adipoinsular axis. Here, we apply circular dichroism (CD) spectropolarimetry and nuclear magnetic resonance (NMR) spectroscopy to characterize the po...

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Detalles Bibliográficos
Autores principales: Shin, Kyungsoo, Sarker, Muzaddid, Huang, Shuya K., Rainey, Jan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684411/
https://www.ncbi.nlm.nih.gov/pubmed/29133807
http://dx.doi.org/10.1038/s41598-017-14784-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684411/
https://www.ncbi.nlm.nih.gov/pubmed/29133807
http://dx.doi.org/10.1038/s41598-017-14784-0

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