O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Cuifang, Gu, Yuchao, Shan, Hui, Mi, Wenyi, Sun, Jiahui, Shi, Minghui, Zhang, Xinling, Lu, Xinzhi, Han, Feng, Gong, Qianhong, Yu, Wengong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684413/
https://www.ncbi.nlm.nih.gov/pubmed/29133780
http://dx.doi.org/10.1038/s41467-017-01654-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684413/
https://www.ncbi.nlm.nih.gov/pubmed/29133780
http://dx.doi.org/10.1038/s41467-017-01654-6

Ejemplares similares