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O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684413/ https://www.ncbi.nlm.nih.gov/pubmed/29133780 http://dx.doi.org/10.1038/s41467-017-01654-6 |