A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I

Antibodies against recombinant proteins can significantly reduce their effectiveness in unanticipated ways. We evaluated the humoral response of mice with the lysosomal storage disease mucopolysaccharidosis type I treated with weekly intravenous recombinant human alpha-l-iduronidase (rhIDU). Unlike...

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Detalles Bibliográficos
Autores principales: Le, Steven Q., Kan, Shih-hsin, Clarke, Don, Sanghez, Valentina, Egeland, Martin, Vondrak, Kristen N., Doherty, Terence M., Vera, Moin U., Iacovino, Michelina, Cooper, Jonathan D., Sands, Mark S., Dickson, Patricia I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684429/
https://www.ncbi.nlm.nih.gov/pubmed/29159202
http://dx.doi.org/10.1016/j.omtm.2017.09.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684429/
https://www.ncbi.nlm.nih.gov/pubmed/29159202
http://dx.doi.org/10.1016/j.omtm.2017.09.008

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