Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits

A total of 28 lapachol-related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine-resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method. Cytot...

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Detalles Bibliográficos
Autores principales: Borgati, Tatiane Freitas, do Nascimento, Maria Fernanda Alves, Bernardino, Juma Fortunato, Martins, Lunamaura Claudia Oliveira, Taranto, Alex Gutterres, de Oliveira, Alaíde Braga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684547/
https://www.ncbi.nlm.nih.gov/pubmed/29225629
http://dx.doi.org/10.1155/2017/7496934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684547/
https://www.ncbi.nlm.nih.gov/pubmed/29225629
http://dx.doi.org/10.1155/2017/7496934

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