Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

Neutralizing CSF1 in vivo completely prevents ovariectomy (OVX)-induced bone loss in mice. There are two isoforms of CSF1, soluble (sCSF1), and membrane-bound (mCSF1), but their individual biological functions are unclear. It had been previously reported that mCSF1 knockout (K/O) and wild type (Wt)...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Gang-Qing, Troiano, Nancy, Simpson, Christine A, Insogna, Karl L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684603/
https://www.ncbi.nlm.nih.gov/pubmed/29152381
http://dx.doi.org/10.1038/boneres.2017.22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684603/
https://www.ncbi.nlm.nih.gov/pubmed/29152381
http://dx.doi.org/10.1038/boneres.2017.22

Ejemplares similares