Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

OBJECTIVE: The aim of the present study was to improve bioavailability of an important antiretroviral drug, Darunavir (DRV), which has low water solubility and poor intestinal absorption through solid dispersion (SD) approach incorporating polymer with P-glycoprotein inhibitory potential. METHODS: A...

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Detalles Bibliográficos
Autores principales: Rehman, Saleha, Nabi, Bushra, Fazil, Mohammad, Khan, Saba, Bari, Naimat Kalim, Singh, Romi, Ahmad, Shavej, Kumar, Varinder, Baboota, Sanjula, Ali, Javed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684613/
https://www.ncbi.nlm.nih.gov/pubmed/29226149
http://dx.doi.org/10.1155/2017/8274927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684613/
https://www.ncbi.nlm.nih.gov/pubmed/29226149
http://dx.doi.org/10.1155/2017/8274927

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