Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich‐cultured human hepatocytes

Farnesoid X receptor (FXR) is a master regulator of bile acid homeostasis through transcriptional regulation of genes involved in bile acid synthesis and cellular membrane transport. Impairment of bile acid efflux due to cholangiopathies results in chronic cholestasis leading to abnormal elevation o...

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Detalles Bibliográficos
Autores principales: Zhang, Yuanyuan, Jackson, Jonathan P., St. Claire, Robert L., Freeman, Kimberly, Brouwer, Kenneth R., Edwards, Jeffrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684861/
https://www.ncbi.nlm.nih.gov/pubmed/28805978
http://dx.doi.org/10.1002/prp2.329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684861/
https://www.ncbi.nlm.nih.gov/pubmed/28805978
http://dx.doi.org/10.1002/prp2.329

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