The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocyti...

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Detalles Bibliográficos
Autores principales: Cosialls, Ana M., Pomares, Helena, Iglesias-Serret, Daniel, Saura-Esteller, José, Núñez-Vázquez, Sonia, González-Gironès, Diana M., de la Banda, Esmeralda, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, González-Barca, Eva M., Gil, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685241/
https://www.ncbi.nlm.nih.gov/pubmed/28619845
http://dx.doi.org/10.3324/haematol.2016.162958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685241/
https://www.ncbi.nlm.nih.gov/pubmed/28619845
http://dx.doi.org/10.3324/haematol.2016.162958

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